Ferritin has good biocompatibility and extremely low immunogenicity, making it one of the most promising tumor nanomedicine carriers. This article aimed to explore the application progress of ferritin as a drug carrier in tumor treatment. It briefly introduced the structure and transport mechanism of ferritin, and focused on the characteristics of ferritin and the role of various functionalization modification strategies in tumor treatment, including tumor targeted modification, the mild conditions such as pH value and temperature required to change encapsulation and control drug release. Finally, the prospects and challenges faced by the current application of ferritin in tumor clinical treatment were discussed.