Drug clinical trial is an important stage in the process of new drug development, and the results of trials become the main basis for drug registration and marketing. Clinical trial drugs are the core of the whole drug clinical trial, and the standardized management of clinical trial drugs is the key to ensure the safety of subjects and the quality of clinical trials. This article analyzes the drawbacks of the current traditional artificial management mode, and combines the experience of the hospital in the establishment and application of drug information management mode to explore the standardized management mode of investigational drugs, in order to improve the level of clinical trial drug management, ensure the safe, orderly, and smooth implementation of trial projects, and provide reference for the wide application of drug information management mode, and explore practical ideas for high-quality management of clinical trial institutions under new circumstances.