Objective To investigate the cancer subjects'awareness of patient-centric clinical trials, their willingness to participate and their influencing factors, in order to explore how to promote patient-centric clinical trials come to fruition from the patients' perspective.Methods Convenience sampling method was used to conduct a questionnaire survey on cancer subjects who participated in clinical trials between March and August 2023 at the Cancer Hospital of the Chinese Academy of Medical Sciences.Results There were 403 (95.7%) valid questionnaires. Only 24.3% cancer subjects had some awareness of patient-centric clinical trials. But there was a high overall willingness (70.0%) to participate in patient-centric clinical trials, especially in the sessions of remote delivery of medication (88.6%) and remote visits (86.6%). The results of univariate analysis showed that the location of patients, presence of religion, length of tumor diagnosis, and number of visits to the institution for clinical trial participation were significantly associated with their willingness to participate in patient-centered clinical trials (P<0.05). The results of multivariate logistic regression analysis showed a high willingness to participate among patients with a tumor diagnosis >5 years and ≥4 visits to the institution for clinical trial participation.Conclusion Cancer patients have a high willingness to participate in patient-centric clinical trials. Using remote technology to reduce the burden on patients, and fully considering the concerns of patients about safety, privacy and full right to know, have a positive significance for the implementation of patient-centric clinical trials.