替雷利珠单抗致免疫性肺炎的药学监护<sup>★</sup>

doi:10.3969/j.issn.2095-1264.2024.05.19

首页 > 过刊浏览>2024年第5期 >641-644. DOI:10.3969/j.issn.2095-1264.2024.05.19

替雷利珠单抗致免疫性肺炎的药学监护★
DOI:
                        10.3969/j.issn.2095-1264.2024.05.19
                    
作者:
                        
                        
                    
作者单位:1.湖北省荆门市中医医院(市石化医院)，药学部，湖北 荆门，448000;2.湖北省荆门市中医医院(市石化医院)，肿瘤血液病科，湖北 荆门，448000;3.北京大学人民医院 药学部，北京，100044
作者简介:刘青，女，副主任药师，研究方向为肿瘤药学。
通讯作者:左小明，男，主管中药师，研究方向为医院药学。
中图分类号:R735.8;R730.6
基金项目:★白求恩·求索-药学科研能力建设项目（B-19-H-20200622）；“聚火优才”全国药学服务科研项目。

Pharmaceutical care of immune-associated pneumonia induced by tislelizumab ^★

Author:

Affiliation:

1.Department of Pharmacy, the Traditional Chinese Medicine Hospital of Jingmen City/Jingmen City Petrochemical Hospital, Jingmen, 448000, Hubei, China;2.Department of Tumor Hematology, the Traditional Chinese Medicine Hospital of Jingmen City/Jingmen City Petrochemical Hospital, Jingmen, 448000, Hubei, China;3.Department of Pharmacy, Peking University People's Hospital, Beijing, 100044, China

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摘要:

1例71岁胆囊癌女性患者接受3个周期替雷利珠单抗免疫治疗后，第12天出现胸闷、咳痰症状，活动后加重，活动后最低指血氧饱和度84%，肺部CT提示重症感染。临床药师通过参与糖皮质激素剂量方案的制订与调整，为患者提供个体化药学服务。替雷利珠单抗致免疫性肺炎虽然常见，但较为严重，应及时采取相应的措施，监护患者电解质、血糖、血压、消化道出血等变化，确保临床用药安全。

Abstract:

A 71-year-old woman received 3 cycles of tislelizumab immunotherapy for gallbladder cancer. Symptoms of chest tightness and sputum appeared on the 12th day after immunotherapy, and were worsened after activity. After exercise, the oxygen saturation of finger blood was 84% at the lowest, and pulmonary CT showed severe infection. Clinical pharmacists provided individualized pharmaceutical care for the patient by participating in the formulation and adjustment of glucocorticoid dose regimen. Immune-associated pneumonia caused by tislelizumab is common, but it is serious. Corresponding measures should be taken in time to monitor the changes of electrolyte, blood sugar, blood pressure and gastrointestinal bleeding in patients to ensure the safety of clinical medication.