姜黄素及其纳米制品对口腔癌预防及治疗的研究进展

doi:10.3969/j.issn.2095-1264.2024.05.04

首页 > 过刊浏览>2024年第5期 >543-547. DOI:10.3969/j.issn.2095-1264.2024.05.04

姜黄素及其纳米制品对口腔癌预防及治疗的研究进展
DOI:
                        10.3969/j.issn.2095-1264.2024.05.04
                    
作者:
                        
                        
                    
作者单位:哈尔滨医科大学附属第四医院 口腔科，黑龙江 哈尔滨，150001
作者简介:赵磊，女，硕士研究生，住院医师，研究方向为口腔颌面外科。
通讯作者:孟培松，女，硕士，主任医师，研究方向为口腔颌面外科。
中图分类号:R739.8
基金项目:★哈尔滨市科技创新人才研究专项基金项目（2014RFXGJ095）；哈尔滨医科大学附属第四医院特别资助项目，（ HYDSYTB201915）。

Research progress of curcumin and its nanoproducts in prevention and treatment of oral cancer

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Department of Stomatology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin,150001, Heilongjiang, China

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摘要:

姜黄素是一种天然酚类化合物，具有抗炎和抗肿瘤等作用，目前在喉癌、肝癌和牙周炎等多种疾病的研究中已取得较为可观的成果。近年来，应用冻干等方法制备得到的纳米级姜黄素制品也逐渐引起人们的重视。本文综合了目前国内外应用姜黄素及其纳米制品对口腔癌的治疗研究进展，证实姜黄素具有促进口腔癌细胞凋亡和自噬等作用；同时，总结目前姜黄素及其纳米制品联合放疗、化疗、光动力、声动力和其他天然药物等多种方法对口腔癌的治疗研究及姜黄素对口腔癌的预防作用，进一步肯定姜黄素作为抗癌药物具有广阔的应用前景，并希冀为未来口腔癌的预防和治疗提供思路。

Abstract:

Curcumin is a natural phenolic compound with anti-inflammatory and anti-tumor effects. At present, it has made considerable achievements in the research of laryngeal cancer, liver cancer, periodontitis and other diseases. In recent years, nanoscale curcumin products prepared by freeze-drying and other methods have gradually attracted people's attention. In this paper, the research progress of curcumin and its nanoproducts in the treatment of oral cancer at home and abroad was reviewed. It was confirmed that curcumin can promote the apoptosis and autophagy of oral cancer cells. In addition, this review summarized the current research on curcumin and its nanoproducts combined with radiotherapy, chemotherapy, photodynamic, sonodynamic and other natural drugs in the treatment of oral cancer, and the preventive effect of curcumin on oral cancer, further affirming that curcumin has a broad application prospect as an anticancer drug. It is hoped to provide ideas for the prevention and treatment of oral cancer in the future.