Angiogenesis is a biological processin which endothelial cells form new capillaries through proliferation, migration and structural modification on the basis of original capillaries.This process is closely related to the occurrence and development of malignant tumors and the prognosis of patientswith tumor. Studies have found the involvement of long non-coding RNAs (lncRNAs) in regulating tumor angiogenesis through different mechanisms: the vast majority of lncRNAs are involved in the regulation of angiogenesis through the competitive endogenous RNA mechanism. In addition, lncRNAs can also regulate angiogenesis by participating in various signaling pathways, including the AKT pathway, or directly affect the expression of proangiogenic factors represented by vascular endothelial growth factor to regulate angiogenesis at the transcriptional level and post-transcriptional level. The author briefly reviewed the research progress of lncRNAs in regulating tumor angiogenesis. Antiangiogenic therapy by targeting lncRNAs could provide a new strategy for cancer treatment.