胃癌组织中自噬相关蛋白与上皮间质转化的关系及意义<sup>★</sup>

doi:10.3969/j.issn.2095-1264.2023.04.12

首页 > 过刊浏览>2023年第4期 >475-479. DOI:10.3969/j.issn.2095-1264.2023.04.12

胃癌组织中自噬相关蛋白与上皮间质转化的关系及意义★
DOI:
                        10.3969/j.issn.2095-1264.2023.04.12
                    
作者:
                        
                        
                    
作者单位:1.鄂南肿瘤医院 肿瘤二科，湖北 赤壁，437300;2.解放军联勤保障部队第922医院 血液肿瘤科，湖南 衡阳，421001;3.南华大学附属第二医院 消化内科，湖南 衡阳，421001
作者简介:王小文，硕士，副主任医师，研究方向：肿瘤。
通讯作者:朱晓芸，主管护师，研究方向：肿瘤护理。
中图分类号:R735.2
基金项目:★衡阳市科技局2019年指导性项目（139）。

Relationship between autophagy-related proteins and epithelial-mesenchymal transition in gastric cancer^★

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Affiliation:

1.Oncology Department 2, Southern Hubei Cancer Hospital, Chibi, 437300, Hubei, China;2.Department of Hematology and Oncology, PLA Joint Support Force 922 Hospital, Hengyang, 421002, Hunan, China;3.Department of Gastroenterology, Second Affiliated Hospital of South China University, Hengyang, 421001, Hunan, China

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摘要:

目的探讨胃癌组织中自噬蛋白微管相关蛋白轻链3B（LC3B）和上皮间质转化（EMT）标志物的表达及其临床意义。方法随机选取2018年1月—2019年12月我院收治的胃癌患者术后癌组织110例和癌旁组织40例，采用免疫组织化学法检测LC3B、E-cadherin和vimentin的表达，并分析这些标志物与胃癌患者临床病理特征的关系。结果与癌旁正常组织相比，胃癌组织中LC3B和vimentin蛋白表达水平显著升高，E-cadherin表达水平显著降低（P<0.05）；LC3B、E-cadherin和vimentin表达水平与肿瘤分化程度、T分期、TNM分期及淋巴结转移密切相关（P<0.05），与年龄、性别和肿瘤大小无关（P>0.05）；LC3B表达与vimentin呈正相关（r=0.320， P=0.001），与E-cadherin呈负相关（r=-0.484， P<0.001）。结论胃癌组织中LC3B、vimentin表达上调，E-cadherin表达下调，且三者与肿瘤分化程度、T分期、TNM分期及淋巴结转移密切相关，可能作为预测胃癌的潜在生物标志物。

Abstract:

Objective To investigate the expression and clinical significance of autophagy protein microtubule-associated protein 1 light chain 3B (LC3B) and epithelial-mesenchymal transition (EMT) markers in gastric cancer.Methods After surgery for gastric cancer patients from January 2018 to December 2019, 110 cases of gastric cancer tissue and 40 cases of paracancerous tissue were randomly selected. The expression of LC3B, E-cadherin and vimentin were detected by immunohistochemistry and the relationship between these markers and clinicopathological features of gastric cancer was analyzed.Results Compared with the expression of LC3B and vimentin in adjacent normal tissues, the expression of LC3B and vimentin in GC was upregulated, while the expression of E-cadherin was downregulated (P<0.05). The expressions of LC3B, E-cadherin and vimentin were closely correlated with the tumor differentiation, T stage, TNM stage and lymph node metastasis (P<0.05), but not with age, gender and tumor size (P>0.05). LCB expression was positively correlated with vimentin (r=0.320, P=0.001), and negatively correlated with E-cadherin (r=-0.484, P<0.001).Conclusion The expression of LC3B and vimentin increased, while the expression of E-cadherin decreased in GC. The expression of LC3B, E-cadherin and vimentin was closely related to tumor differentiation, T stage, TNM stage and lymph node metastasis. The expression of these markers may be used as potential biomarkers for predicting gastric cancer.