重楼皂苷化学成分及抗肿瘤作用研究进展

doi:10.3969/j.issn.2095-1264.2022.03.08

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重楼皂苷化学成分及抗肿瘤作用研究进展
DOI:
                        10.3969/j.issn.2095-1264.2022.03.08
                    
作者:
                        
                        
                    
作者单位:重庆第二师范学院/三峡库区药用资源重庆市重点实验室，重庆，400067
作者简介:聂芩，女，硕士研究生，研究方向：药物分析及药物代谢动力学。
通讯作者:况刚，男，硕士，副主任中药师，研究方向：中药药理及药物分析。
中图分类号:R96
基金项目:

Advances in the study of the chemical composition and anti-tumor effects of Rhizoma Paridis saponins

Author:

Affiliation:

Chongqing University of Education/The Key Laboratory of the Medicinal Resources of Chongqing in the Three Gorges Reservoir Area, Chongqing, 400067, China

Fund Project:

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摘要:

重楼是我国常用的抗肿瘤药物，资源丰富，主要分布于四川、云南等地。大量研究发现，重楼的主要活性成分为皂苷类，包括50多种化合物，其中具有抗肿瘤作用的成分为重楼皂苷Ⅰ、Ⅱ、Ⅵ、Ⅶ等，对肝癌、肺癌、膀胱癌、骨肉瘤、神经胶质瘤等多种恶性肿瘤均具有抑制作用。本文梳理了重楼皂苷的主要活性成分、抗肿瘤作用以及分子作用机制，以期为重楼皂苷类药物的开发和利用提供参考依据，并为其在抗肿瘤临床治疗中的应用提供基础来源。

Abstract:

Rhizoma Paridis is an anti-tumor drug commonly used in China. It is rich in China, mainly distributed in Sichuan, Yunnan and other places. A large number of studies have found that the main active components of Rhizoma Paridis are saponins, including more than 50 compounds. Among them, the anti-tumor components are Rhizoma Paridis saponin Ⅰ, Ⅱ, Ⅵ, Ⅶ, etc., which have inhibitory effects on lung cancer, bladder cancer, osteosarcoma, glioma and other malignant tumors. In this review, the main active components, anti-tumor effects and molecular action mechanisms of Rhizoma Paridis saponins were summarized, in order to provide references for the development and utilization of Rhizoma Paridis saponins, and basic sources for their application in clinical anti-tumor treatment.