Abstract:Rhizoma Paridis is an anti-tumor drug commonly used in China. It is rich in China, mainly distributed in Sichuan, Yunnan and other places. A large number of studies have found that the main active components of Rhizoma Paridis are saponins, including more than 50 compounds. Among them, the anti-tumor components are Rhizoma Paridis saponin Ⅰ, Ⅱ, Ⅵ, Ⅶ, etc., which have inhibitory effects on lung cancer, bladder cancer, osteosarcoma, glioma and other malignant tumors. In this review, the main active components, anti-tumor effects and molecular action mechanisms of Rhizoma Paridis saponins were summarized, in order to provide references for the development and utilization of Rhizoma Paridis saponins, and basic sources for their application in clinical anti-tumor treatment.