Objective To explore the clinical pharmacist's participation in the staged pharmaceutical care model for inpatients with colorectal cancer (CRC).Methods Develop the staged pharmaceutical care model and contents for inpatients with CRC. According to the this model, clinical pharmacist practiced pharmacological care for a patient who got FOLFIRI (irinotecan+calcium levofolinate+fluorouracil) chemotherapy and developed grade 3 delayed-onset diarrhea and grade 2 oral ulcers. Specific contents included pharmacological care such as examination of liver and kidney function and blood routine, evaluation of degrees of previous adverse reactions, assessment of chemotherapy drug dose adjustment before chemotherapy; rationality of pretreatment of chemotherapy drugs, evaluation of vomiting level of chemotherapy drugs and its monitoring during chemotherapy; adverse reaction monitoring, discharge drug advice, and medication education after chemotherapy.Results With the implementation of the staged pharmaceutical care model, the patient received individualized treatment plans, and the adverse drug reactions were discovered and intervened in time.Conclusion By formulating a staged pharmaceutical care model, clinical pharmacists can take effective pharmaceutical care for inpatients with colorectal cancer. This model provides a reference for clinical pharmacists to participate in the clinical drug treatment work.