Cancerous fever is a common complication in patients with advanced malignant tumor. It is caused by the tumor disease itself, but having no relation with the infection. Generally, it is symptomatically treated in Western medicine, but anti-infective treatment is usually ineffective. Traditional Chinese medicine usually takes the treatment based on syndrome differentiation, and considers most cancerous fever as the Yin deficiency fever. Qinghao Biejia decoction has a good effect on this type of cancer fever. Based on the theory of traditional Chinese medicine and the knowledge of modern pharmacology, this paper analyzed the prescription of Qinghao Biejia decoction and discussed on the treatment of cancerous fever with equal emphasis on clearing heat and nourishing Yin.