Cervical cancer is one of the common gynecological malignant tumors. The occurrence and development of cervical cancer is a complex process in which multiple factors work together. A lack of folic acid has been linked to cervical cancer in some studies. MTHFR and MTRR genes are important factors in the expression level of folic acid. Both are key enzymes in folic acid metabolic pathways. MTHFR is a key enzyme that reduces 5, 10-methylene tetrahydrofolate to 5-methyl-tetrahydrofolate, which provides the raw material for the methyl cycle and maintains the normal methylation of DNA. This is the main form of the folic acid cycle. MTRR is an auxiliary enzyme, and its gene polymorphism has been reported to be associated with the occurrence of cancer. However, whether folic acid deficiency is a risk factor or an increase in susceptibility to cervical carcinoma is controversial and inconclusive. Therefore, the purpose of this article is to review the progress of studies on the relationship between folic acid level and gene polymorphism of key enzymes involved in its metabolism and cervical carcinoma.