急性放射性皮炎防治研究进展

doi:10.3969/j.issn.2095-1264.2021.05.02

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急性放射性皮炎防治研究进展
DOI:
                        10.3969/j.issn.2095-1264.2021.05.02
                    
作者:
                        
                        
                    
作者单位:1.南华大学衡阳医学院，湖南省肿瘤医院研究生协作培养基地，湖南 衡阳，421001;2.湖南省肿瘤防治研究所， 湖南 长沙，410013
作者简介:曾小玲，女，硕士研究生，研究方向：耳鼻咽喉头颈外科。
通讯作者:戴捷，男，主任医师，研究方向：头颈部肿瘤。
中图分类号:R730.6
基金项目:★湖南省科技厅重点研发计划（2018SK2122）

Progress in prevention and treatment of acute radiation dermatitis^★

Author:

Affiliation:

1.Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China;2.Hunan Provincial Institute for Cancer Research, Changsha, Hunan, 410013, China

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摘要:

急性放射性皮炎是一种由肿瘤放射治疗、职业性或意外事故以及战时核辐射等大剂量射线照射后引起的皮肤损伤，常发生于辐射后数天至数月内。急性放射性皮炎发病机制未完全阐明，目前主要认为与放射线直接或间接诱导细胞DNA损伤，引起细胞凋亡、坏死相关。现代医学对急性放射性皮炎有效防治尚无统一共识。本文旨在将近年来针对急性放射性皮炎药物和物理防治研究作一综述，以期为今后的临床治疗和学术研究提供科学参考和研究方向。

Abstract:

Acute radiation dermatitis is a skin injury caused by large doses of radiation such as tumor radiotherapy, occupational or accidental accidents, and wartime nuclear radiation, often occurring within days to months after radiation. At present, the pathogenesis of acute radiation dermatitis is not fully elucidated. It is mainly considered to be related to the direct or indirect induction of cell DNA injury by radiation, resulting in apoptosis and necrosis. There is no consensus on the effective prevention and treatment of acute radiation dermatitis in modern medicine. The purpose of this paper is to review the drug and physical prevention and treatment of acute radiation dermatitis in recent years, in order to provide scientific reference and research direction for clinical treatment and academic research in the future.