Objective To compare the short-term clinical effects of mere chemotherapy and chemotherapy combined with traditional Chinese Integrative Medicine in the treatment of Ⅲ, Ⅳ non-small cell lung cancer. Methods A total of 53 cases of Ⅲ, Ⅳ stage non-small cell lung cancer were included and divided into the traditional Chinese and Western medicine integrative group in which chemotherapy was combined with traditional Chinese medicine for 27 cases, and Western medicine group in which there was mere chemotherapy, for 26 cases. After treatment, the curative effect and one-year survival of patients were compared between the two groups. Results After two courses of treatment, 14 cases had remission in chemotherapy combined with traditional Chinese medicine group (51.9％), 8 cases of patients had disease free-progression (29.6％), and the rest 5 cases had disease deteriorated (18.5％), with a total effective rate of 51.9％. The curative effects were significantly higher than that of simple Western medication group (P>0.05). 13 cases had one-year survival in combined traditional Chinese and Western medicine group with the survival rate of 48.1％, and there was no significant difference in one-year survival rates between the two groups (P>0.05). The local recurrence and distant metastasis rate was of no significant difference in the follow-up of one year. Conclusion Chemotherapy combined with traditional Chinese medicine therapy had optimum short-term effects on Ⅲ, Ⅳ stage non-small cell lung cancer.