Traditional channels for recruiting subjects in clinical trials often suffer from limitations such as inefficiency and prolonged recruitment periods. To address this, this study leveraged the hospital information system (HIS) and integrated Tencent-based platforms, including official hospital WeChat accounts, to develop an intelligent recruitment and screening information system. The system established a two-way selection mechanism between investigators and potential subjects, which significantly reduced the consumption of manpower and material resources. By utilizing informatization strategies, this intelligent system optimized the recruitment process, enhancing both efficiency and quality. Furthermore, it achieved effective integration of hospital resources and clinical trial data, thereby facilitating the transformation and application of clinical data. This study provided valuable insights for the development and upgrading of intelligent recruitment platforms in clinical research.