BMI1在肿瘤中的研究进展<sup>★</sup>

doi:10.3969/j.issn.2095-1264.2023.06.04

首页 > 过刊浏览>2023年第6期 >675-685. DOI:10.3969/j.issn.2095-1264.2023.06.04

BMI1在肿瘤中的研究进展★
DOI:
                        10.3969/j.issn.2095-1264.2023.06.04
                    
作者:
                        
                        
                    
作者单位:湖南师范大学医学院 小分子靶向药物研究与创制湖南省重点实验室，湖南 长沙，410013
作者简介:张芝榕，女，硕士研究生，研究方向：肿瘤药理及小分子靶向药物创制。
通讯作者:彭美，女，博士研究生，研究方向：肿瘤药理及小分子靶向药物创制。
中图分类号:R730
基金项目:★小分子靶向药物研究与创制湖南省重点实验室和湖南师范大学交叉团队项目（2023JC101）。

Research progress of BMI1 in cancer^★

Author:

Affiliation:

Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, China

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摘要:

B细胞特异性莫洛尼鼠白血病病毒整合位点1（BMI1）作为多梳基因（PcG）家族的重要成员，参与调控细胞增殖与分化，与肿瘤的发生发展密切相关。作为原癌基因，BMI1在人类多种肿瘤中过表达，通过多种途径如促进肿瘤细胞增殖、维持肿瘤细胞干性、促进DNA损伤修复等来参与肿瘤的发生发展。本文总结了BMI1的分子结构与功能、上游调控机制及其与肿瘤细胞增殖、肿瘤免疫微环境、肿瘤细胞干性和DNA损伤修复的关系和引起的信号通路变化，并对BMI1在化疗耐药中的作用和BMI1小分子抑制剂的开发现状进行综述。

Abstract:

BMI1 (B lymphoma Mo-MLV insertion region 1), an important member of the polycomb gene (PcG) family, plays crucial roles in regulating cell proliferation and differentiation and is related to the occurrence and development of tumors. As a proto-oncogene, BMI1 is overexpressed in various human cancers. It participates in tumor development through various pathways such as promoting tumor cell proliferation, maintaining tumor cell stemness, and promoting DNA damage repair. The review focused on the molecular structure and function of BMI1, upstream regulatory mechanisms, as well as the relationship between BMI1 and tumor cell proliferation, tumor immune microenvironment, tumor cell stemness and DNA damage repair, and the changes in signaling pathways caused by BMI1. In addition, the review also summarized the role of BMI1 in chemotherapy resistance, as well as current agents targeting BMI1.